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Behavioural Analyses of Quinine Processing in Choice, Feeding and Learning of Larval Drosophila

Please always quote using this URN: urn:nbn:de:bvb:20-opus-130811
  • Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0 mM) than is the case for internal reinforcement (0.6 mM). Interestingly, in previous studies (Niewalda et al. 2008, Schipanski et al 2008) we had found the reverse for sodium chloride and fructose/sucrose, such that dose-effect functions for those tastants were shifted towards lower concentrations for feeding as compared to reinforcement, arguing that the differences in dose-effect function between these behaviours do not reflect artefacts of the types of assay used. The current results regarding quinine thus provide a starting point to investigate how the gustatory system is organized on the cellular and/or molecular level to result in different behavioural tuning curves towards a bitter tastant.show moreshow less

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Metadaten
Author: Amira El-Keredy, Michael Schleyer, Christian König, Aslihan Ekim, Bertram Gerber
URN:urn:nbn:de:bvb:20-opus-130811
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):PLoS One
Year of Completion:2012
Volume:7
Issue:7
Pagenumber:e40525
Source:PLoS ONE 7(7): e40525. doi:10.1371/journal.pone.0040525
DOI:https://doi.org/10.1371/journal.pone.0040525
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:architecture; bitter taste; brain; chemosensory system; honeybees; melanogaster; organization; perception; receptor; reward
Release Date:2016/12/01
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung