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Autoimmunity, dendritic cells and relevance for Parkinson’s disease
Please always quote using this URN: urn:nbn:de:bvb:20-opus-132308
- Innate and adaptive immune responses in neurodegenerative diseases have become recently a focus of research and discussions. Parkinson’s disease (PD) is a neurodegenerative disorder without known etiopathogenesis. The past decade has generated evidence for an involvement of the immune system in PD pathogenesis. Both inflammatory and autoimmune mechanisms have been recognized and studies have emphasized the role of activated microglia and T-cell infiltration. In this short review, we focus on dendritic cells, on their role in initiation ofInnate and adaptive immune responses in neurodegenerative diseases have become recently a focus of research and discussions. Parkinson’s disease (PD) is a neurodegenerative disorder without known etiopathogenesis. The past decade has generated evidence for an involvement of the immune system in PD pathogenesis. Both inflammatory and autoimmune mechanisms have been recognized and studies have emphasized the role of activated microglia and T-cell infiltration. In this short review, we focus on dendritic cells, on their role in initiation of autoimmune responses, we discuss aspects of neuroinflammation and autoimmunity in PD, and we report new evidence for the involvement of neuromelanin in these processes.…
Author: | E. Koutsilieri, M. B. Lutz, C. Scheller |
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URN: | urn:nbn:de:bvb:20-opus-132308 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Language: | English |
Parent Title (English): | Journal of Neural Transmission |
Year of Completion: | 2013 |
Volume: | 120 |
Pagenumber: | 75-81 |
Source: | Journal of Neural Transmission (2013) 120:75–81 DOI 10.1007/s00702-012-0842-7 |
DOI: | https://doi.org/10.1007/s00702-012-0842-7 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Tag: | Parkinson; autoimmunity; dendritic cells; immune neuromelanin |
Release Date: | 2016/06/11 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |