Description and Nomenclature of Neisseria meningitidis Capsule Locus
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- Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomalPathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.…
Autor(en): | Odile B. Harrison, Heike Claus, Ying Jiang, Julia S. Bennett, Holly B. Bratcher, Keith A. Jolley, Craig Corton, Rory Care, Jan T. Poolman, Wendell D. Zollinger, Carl E. Frasch, David S. Stephens, Ian Feavers, Matthias Frosch, Julian Parkhill, Ulrich Vogel, Michael A. Quail, Stephen D. Bentley, Martin C. J. Maiden |
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URN: | urn:nbn:de:bvb:20-opus-131703 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Hygiene und Mikrobiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Emerging Infectious Diseases |
Erscheinungsjahr: | 2013 |
Band / Jahrgang: | 19 |
Heft / Ausgabe: | 4 |
Seitenangabe: | 566-573 |
Originalveröffentlichung / Quelle: | Emerging Infectious Diseases Vol. 19, No. 4, 566-573. DOI: http://dx.doi.org/10.3201/eid1904.111799 |
DOI: | https://doi.org/10.3201/eid1904.111799 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Freie Schlagwort(e): | antigen; biosynthesis; chemical properties; elucidation; genetics; group-B; meningococcal polysaccharides; nuclear magnetic resonance; serogroup-Y; structural determination |
Datum der Freischaltung: | 23.05.2016 |
Lizenz (Deutsch): | CC 0: Public Domain Dedication |