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Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study

Please always quote using this URN: urn:nbn:de:bvb:20-opus-170406
  • Objective: To investigate the association between levodopa‐induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. Methods: This study included 13 Parkinson's disease patients with peak‐of‐dose levodopa‐induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5‐[\(^{123}\)I]iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine single‐photon emission computed tomography, a marker of nicotinic acetylcholine receptors,Objective: To investigate the association between levodopa‐induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. Methods: This study included 13 Parkinson's disease patients with peak‐of‐dose levodopa‐induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5‐[\(^{123}\)I]iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine single‐photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [\(^{123}\)I]N‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane single‐photon emission computed tomography, to measure dopamine reuptake transporter density and 2‐[\(^{18}\)F]fluoro‐2‐deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed. Results: Density of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side. Interpretation: Our findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic‐depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression.show moreshow less

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Metadaten
Author: Joachim Brumberg, Sebastian Küsters, Ehab Al-Momani, Giorgio Marotta, Kelly P. Cosgrove, Christopher H. van Dyck, Ken Herrmann, György A. Homola, Gianni Pezzoli, Andreas K. Buck, Jens Volkmann, Samuel Samnick, Ioannis U. Isaias
URN:urn:nbn:de:bvb:20-opus-170406
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin
Medizinische Fakultät / Neurologische Klinik und Poliklinik
Medizinische Fakultät / Abteilung für Neuroradiologie
Language:English
Parent Title (English):Annals of Clinical and Translational Neurology
Year of Completion:2017
Volume:4
Issue:9
Pagenumber:632–639
Source:Annals of Clinical and Translational Neurology 2017; 4(9):632-639. DOI: 10.1002/acn3.438
DOI:https://doi.org/10.1002/acn3.438
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28904985
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Parkinson’s disease; cholinergic activity; levodopa-induced dyskinesia
Release Date:2019/09/23
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International