Independent natural genetic variation of punishment- versus relief-memory
Please always quote using this URN: urn:nbn:de:bvb:20-opus-186554
- A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbredA painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.…
Author: | Mirjam Appel, Claus-Jürgen Scholz, Samet Kocabey, Sinead Savage, Christian König, Ayse Yarali |
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URN: | urn:nbn:de:bvb:20-opus-186554 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät |
Language: | English |
Parent Title (English): | Biology Letters |
Year of Completion: | 2016 |
Volume: | 12 |
Issue: | 12 |
Pagenumber: | 20160657 |
Source: | Biology Letters (2016) 12:12, 20160657. https://doi.org/10.1098/rsbl.2016.0657 |
DOI: | https://doi.org/10.1098/rsbl.2016.0657 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Drosophila melanogaster; associative memory; fruit-flies; natural genetic variation; opponent processes; punishment; rats; relief; reward |
Release Date: | 2020/05/20 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |