• search hit 1 of 2
Back to Result List

The Role of Sphingomyelin Breakdown in Measles Virus Immunmodulation

Please always quote using this URN: urn:nbn:de:bvb:20-opus-120004
  • Measles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality. MV infections alter many functions of antigen presenting cells (APC) (dendritic cells (DCs)) and lymphocytes, yet many molecular targets of the virus remain poorly defined. Cellular interactions and effector functions of DCs and lymphocytes are regulated by surface receptors. Associating with other proteins involved in cell signaling, receptors form part of receptosomes thatMeasles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality. MV infections alter many functions of antigen presenting cells (APC) (dendritic cells (DCs)) and lymphocytes, yet many molecular targets of the virus remain poorly defined. Cellular interactions and effector functions of DCs and lymphocytes are regulated by surface receptors. Associating with other proteins involved in cell signaling, receptors form part of receptosomes that respond to and transmit external signals through dynamic interctions with the cytoskeleton. Alterations in the composition and metabolism of membrane sphingolipids have a substantial impact on both processes. In this review we focus on the regulation of sphingomyelinase activity and ceramide release in cells exposed to MV and discuss the immunosuppressive role of sphingomyelin breakdown induced by MV.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Elita Avota, Sibylle Schneider-Schaulies
URN:urn:nbn:de:bvb:20-opus-120004
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Language:English
Parent Title (English):Cellular Physiology and Biochemistry
ISSN:1015-8987
Year of Completion:2014
Volume:34
Issue:1
Pagenumber:20-26
Source:Cellular Physiology and Biochemistry 2014;34:20-26. DOI:10.1159/000362981
DOI:https://doi.org/10.1159/000362981
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24977478
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 579 Mikroorganismen, Pilze, Algen
Tag:T cell silencing; dendritic cell; immunosuppression; measles virus; sphingomyelinase
Release Date:2015/11/25
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell