Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives
Please always quote using this URN: urn:nbn:de:bvb:20-opus-223432
- Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F, an apolipoprotein A-I mimetic peptide or antibodiesWithin the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons by activating transient receptor potential ion channels, specifically TRPA1 and TRPV1. Under inflammatory conditions, OxPL-mediated receptor potentials even potentiate the action potential firing rate of nociceptors. Targeting OxPL with D-4F, an apolipoprotein A-I mimetic peptide or antibodies like E06, specifically binding oxidized headgroups of phospholipids, can be used to control acute, inflammatory pain syndromes, at least in rodents. With a focus on proalgesic specificities of OxPL, this article discusses, how targeting defined substances of the epilipidome can contribute to mechanism-based therapies against primary and secondary chronic inflammatory or possibly also neuropathic pain.…
Author: | Beatrice Oehler, Alexander Brack, Robert Blum, Heike L. Rittner |
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URN: | urn:nbn:de:bvb:20-opus-223432 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Klinische Neurobiologie |
Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) | |
Language: | English |
Parent Title (English): | Frontiers in Endocrinology |
ISSN: | 1664-2392 |
Year of Completion: | 2021 |
Volume: | 11 |
Article Number: | 613868 |
Source: | Frontiers in Endocrinology 2021, 11:613868. doi: 10.3389/fendo.2020.613868 |
DOI: | https://doi.org/10.3389/fendo.2020.613868 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | TRP channel; analgesia; ion channel; mimetic peptide; nociception; oxidized phospholipids; pain therapy; therapeutic antibody |
Release Date: | 2021/03/15 |
Date of first Publication: | 2021/01/25 |
Open-Access-Publikationsfonds / Förderzeitraum 2020 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |