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Covalent binding of aflatoxin B\(_1\) to liver DNA in rats pretreated with ethanol

Please always quote using this URN: urn:nbn:de:bvb:20-opus-55237
  • Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen eHJaflatoxin BI (AFBI)' 24 h later, the level of DNA-bound AFBI was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFBI metabolites.

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Metadaten
Author: M. Marinovich, Werner K. Lutz
URN:urn:nbn:de:bvb:20-opus-55237
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Language:English
Parent Title (German):Experientia
Year of Completion:1985
Volume:41
Issue:10
Source:Experientia (1985) 41, 10, 1338-1340.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Toxikologie
Tag:Carcinogenesis; DNA; aflatoxin; covalent binding; ethanol
Release Date:2011/03/30
First Page:1338
Last Page:1340
Licence (German):License LogoDeutsches Urheberrecht