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Salmonella - how a metabolic generalist adopts an intracellular lifestyle during infection

Please always quote using this URN: urn:nbn:de:bvb:20-opus-149029
  • The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infectiveThe human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.show moreshow less

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Metadaten
Author: Thomas Dandekar, Astrid Fieselmann, Eva Fischer, Jasmin Popp, Michael Hensel, Janina Noster
URN:urn:nbn:de:bvb:20-opus-149029
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Frontiers in Cellular and Infection Microbiology
Year of Completion:2015
Volume:4
Issue:191
Source:Frontiers in Cellular and Infection Microbiology 4:191 (2015). DOI: 10.3389/fcimb.2014.00191
DOI:https://doi.org/10.3389/fcimb.2014.00191
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:"-omics"; Salmonella-containing vacuole (SCV); bacterial invasion; defenses; enterica serovar Typhimurium; metabolism; mouse model; nitric oxide; regulation; virulence
Release Date:2018/11/23
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International