Brain metabolic alterations herald falls in patients with Parkinson's disease
Please always quote using this URN: urn:nbn:de:bvb:20-opus-235982
- Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious followup to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal corticalPathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious followup to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.…
Author: | Ioannis U. IsaiasORCiD, Joachim Brumberg, Nicoló G. Pozzi, Chiara Palmisano, Andrea Canessa, Giogio Marotta, Jens Volkmann, Gianni Pezzoli |
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URN: | urn:nbn:de:bvb:20-opus-235982 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin |
Medizinische Fakultät / Neurologische Klinik und Poliklinik | |
Language: | English |
Parent Title (English): | Annals of Clinical and Translational Neurology |
Year of Completion: | 2020 |
Volume: | 7 |
Issue: | 4 |
Pagenumber: | 579-583 |
Source: | Annals of Clinical and Translational Neurology 2020; 7(4): 579–583. doi: 10.1002/acn3.51013 |
DOI: | https://doi.org/10.1002/acn3.51013 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Parkionson's disease; brain metabolic alterations |
Release Date: | 2021/05/10 |
Open-Access-Publikationsfonds / Förderzeitraum 2020 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |