Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-121403
- FAS-associated protein with death domain (FADD) is a major adaptor protein involved in extrinsic apoptosis, embryogenesis, and lymphocyte homeostasis. Although abnormalities of the FADD/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cellFAS-associated protein with death domain (FADD) is a major adaptor protein involved in extrinsic apoptosis, embryogenesis, and lymphocyte homeostasis. Although abnormalities of the FADD/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cell lymphoma development. This immunohistochemical study investigated pFADD protein expression in a range of normal tissues and lymphomas, particularly T-cell lymphomas that require improved therapies. Whereas pFADD was expressed only in scattered normal T cells, it was detected at high levels in T-cell lymphomas (eg, 84% anaplastic large cell lymphoma and 65% peripheral T cell lymphomas, not otherwise specified). The increased expression of pFADD supports further study of its clinical relevance and role in lymphomagenesis, highlighting phosphorylation of FADD as a potential therapeutic target.…
Autor(en): | Suketu Patel, Derek Murphy, Eugenia Haralmbieva, Zainalabideen A. Abdulla, Kah Keng Wong, Hong Chen, Edith Gould, Giovanna Roncador, Chris S. R. Hatton, Amanda P. Anderson, Alison H. Banham, Karen Pulford |
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URN: | urn:nbn:de:bvb:20-opus-121403 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Pathologisches Institut |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Biomarker Insights |
ISSN: | 1177-2719 |
Erscheinungsjahr: | 2014 |
Band / Jahrgang: | 9 |
Seitenangabe: | 77-84 |
Originalveröffentlichung / Quelle: | Biomarker Insights 2014:9 77–84 doi: 10.4137/BMIMI.S16553 |
DOI: | https://doi.org/10.4137/bmi.s16553 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/25232277 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | ALCL; FADD; PTCL; autoantigen; lymphoma; pFADD |
Datum der Freischaltung: | 18.02.2016 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |