T-cell reactivity to purified lipophosphoglycan from Leishmania major: A model for analysis of the cellular immune response to microbial carbohydrates.
Please always quote using this URN: urn:nbn:de:bvb:20-opus-33022
- The major macromolecule on the surface o/Leishmania majorpromastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of para-sites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell Stimulation by this non-protein antigen.
| Author: | Heidrun Moll, Martin Röllinghoff |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-33022 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
| Language: | English |
| Year of Completion: | 1991 |
| Source: | Behring Inst. Mitt. (1991) 88, 161-169. |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | Leishmania; T lymphocytes; glycosyl phosphatidyl-inostitols. |
| Release Date: | 2009/01/20 |