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The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature

Please always quote using this URN: urn:nbn:de:bvb:20-opus-370110
  • Vitamin D is considered to play an important role in musculoskeletal health. It’s classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almostVitamin D is considered to play an important role in musculoskeletal health. It’s classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.show moreshow less

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Metadaten
Author: Gerrit S. Maier, Manuel Weissenberger, Maximilian Rudert, Klaus E. Roth, Konstantin Horas
URN:urn:nbn:de:bvb:20-opus-370110
Document Type:Journal article
Faculties:Medizinische Fakultät / Lehrstuhl für Orthopädie
Language:English
Parent Title (English):Annals of Translational Medicine
Year of Completion:2021
Volume:9
Article Number:942
Source:Annals of Translational Medicine (2021) 9:942. https://doi.org/10.21037/atm-21-779
DOI:https://doi.org/10.21037/atm-21-779
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:orthopaedics; orthopedics; traumatology; vitamin D; vitamin D deficiency (VDR)
Release Date:2024/09/18
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International