Five year follow up of extremely low gestational age infants after timely or delayed administration of routine vaccinations
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- This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants <29 weeks of gestation. Univariate analysis and logistic/linearThis study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants <29 weeks of gestation. Univariate analysis and logistic/linear regression models were used to identify risk factors for vaccination delay and outcomes at a 5-year follow-up. In our cohort n = 824 (9.8%) ELGANs did not receive a timely first immunization with the hexavalent and pneumococcal vaccine. Risk factors for delayed vaccination were SGA status (18.1% vs. 13.5%; OR 1.3; 95% CI: 1.1–1.7), impaired growth and surrogates for complicated clinical courses (i.e., need for inotropes, necrotizing enterocolitis). At 5 years of age, timely immunized children had a lower risk of bronchitis (episodes within last year: 27.3% vs. 37.7%; OR 0.60, 95% CI: 0.42–0.86) but spirometry measures were unaffected. In conclusion, a significant proportion of ELGANs are untimely immunized, specifically those with increased vulnerability, even though they might particularly benefit from the immune-promoting effects of a timely vaccination.…
Autor(en): | Ingmar Fortmann, Marie-Theres Dammann, Alexander Humberg, Bastian Siller, Guido Stichtenoth, Geraldine Engels, Janina Marißen, Kirstin Faust, Kathrin Hanke, Sybelle Goedicke-Fritz, Christoph Derouet, Sascha Meyer, Regine Stutz, Elisabeth Kaiser, Egbert Herting, Wolfgang Göpel, Christoph Härtel, Michael Zemlin |
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URN: | urn:nbn:de:bvb:20-opus-239592 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Kinderklinik und Poliklinik |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Vaccines |
ISSN: | 2076-393X |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 9 |
Heft / Ausgabe: | 5 |
Aufsatznummer: | 493 |
Originalveröffentlichung / Quelle: | Vaccines (2021) 9:5, 493. https://doi.org/10.3390/vaccines9050493 |
DOI: | https://doi.org/10.3390/vaccines9050493 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | immunization; long-term outcome; prematurity; trained immunity |
Datum der Freischaltung: | 05.09.2022 |
Datum der Erstveröffentlichung: | 12.05.2021 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |