Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives
Please always quote using this URN: urn:nbn:de:bvb:20-opus-96937
- Immunotherapy of malignant gliomas with autologous dendritic cells (DCs) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10–15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and several studies with a non-vaccinated controlImmunotherapy of malignant gliomas with autologous dendritic cells (DCs) in addition to surgery and radiochemotherapy has been a focus of intense research during the past decade. Since both children and adults are affected by this highly aggressive brain tumor, 10–15% of the several hundred vaccinated patients represent children, making pediatric glioma patients the largest uniform pediatric vaccination cohort so far. In general, DC vaccination in malignant gliomas has been shown to be safe and several studies with a non-vaccinated control group could clearly demonstrate a survival benefit for the vaccinated patients. Interestingly, children and adolescents below 21 years of age seem to benefit even more than adult patients. This review summarizes the findings of the 25 clinical trials published so far and gives a perspective how DC vaccination could be implemented as part of multimodal therapeutic strategies in the near future.…
Author: | Matthias Eyrich, Johannes Rachor, Susanne C. Schreiber, Matthias Wölfl, Paul G. Schlegel |
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URN: | urn:nbn:de:bvb:20-opus-96937 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Kinderklinik und Poliklinik |
Language: | English |
Parent Title (English): | Frontiers in Pediatrics |
Year of Completion: | 2013 |
Source: | In: Frontiers in Pediatrics (2013) 1: 12, doi:10.3389/fped.2013.00012 |
DOI: | https://doi.org/10.3389/fped.2013.00012 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | DC vaccination; clinical trial; immunotherapy; malignant glioma; pediatrics |
Release Date: | 2014/04/30 |
Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2013 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |