Tissue models for Neisseria gonorrhoeae research — from 2D to 3D
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-263046
- Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second most common sexually transmitted infection worldwide. Disease progression, drug discovery, and basic host-pathogen interactions are studied using different approaches, which rely on models ranging from 2D cell culture to complex 3D tissues and animals. In this review, we discuss the models used in N. gonorrhoeae research. We address both in vivo (animal) and in vitro cell culture models, discussing the pros and cons of each and outlining the recent advancementsNeisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second most common sexually transmitted infection worldwide. Disease progression, drug discovery, and basic host-pathogen interactions are studied using different approaches, which rely on models ranging from 2D cell culture to complex 3D tissues and animals. In this review, we discuss the models used in N. gonorrhoeae research. We address both in vivo (animal) and in vitro cell culture models, discussing the pros and cons of each and outlining the recent advancements in the field of three-dimensional tissue models. From simple 2D monoculture to complex advanced 3D tissue models, we provide an overview of the relevant methodology and its application. Finally, we discuss future directions in the exciting field of 3D tissue models and how they can be applied for studying the interaction of N. gonorrhoeae with host cells under conditions closely resembling those found at the native sites of infection.…
Autor(en): | Motaharehsadat Heydarian, Eva Rühl, Ravisha Rawal, Vera Kozjak-Pavlovic |
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URN: | urn:nbn:de:bvb:20-opus-263046 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Cellular and Infection Microbiology |
ISSN: | 2235-2988 |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 12 |
Aufsatznummer: | 840122 |
Originalveröffentlichung / Quelle: | Frontiers in Cellular and Infection Microbiology (2022) 12:840122. doi:10.3389/fcimb.2022.840122 |
DOI: | https://doi.org/10.3389/fcimb.2022.840122 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | Neisseria gonorrhoeae; biomimetic tissue models; ex vivo; in vitro; in vivo |
Datum der Freischaltung: | 30.01.2023 |
Datum der Erstveröffentlichung: | 11.02.2022 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |