Denileukin Diftitox plus Total Skin Electron Beam Radiation in Patients with Treatment-refractory Cutaneous T-cell Lymphoma (Mycosis Fungoides): Report of Four Cases
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- Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL) (1). Most patients initially respond well to standard therapy, but advanced MF is often treatment refractory. Thus, a combination of the available treatment options is an important strategy. Total skin electron beam radiation (TSEB) is effective in MF, with a complete remission rate of up to 90% in the early stages. However, in patients with more advanced stages, remission rates are considerably lower (2, 3). Denileukin diftitox (DD) (Ontak®) is a recombinant fusionMycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL) (1). Most patients initially respond well to standard therapy, but advanced MF is often treatment refractory. Thus, a combination of the available treatment options is an important strategy. Total skin electron beam radiation (TSEB) is effective in MF, with a complete remission rate of up to 90% in the early stages. However, in patients with more advanced stages, remission rates are considerably lower (2, 3). Denileukin diftitox (DD) (Ontak®) is a recombinant fusion protein of the receptor-binding domain of interleukin (IL)-2 and the enzymatic and translocation domains of diphtheria toxin (4). It targets the alpha-subunit of the IL-2-receptor (CD25). There are no reports on this combination therapy in MF.…
Autor(en): | Kristina Buder, Philip A. Müller, Gabriele Beekmann, Selma Ugurel, Eva-Bettina Bröcker, Jürgen C. Becker |
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URN: | urn:nbn:de:bvb:20-opus-120091 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Acta Dermato-Venereologica |
Erscheinungsjahr: | 2014 |
Band / Jahrgang: | 94 |
Seitenangabe: | 94-96 |
Originalveröffentlichung / Quelle: | Acta Dermato-Venereologica 2014; 94: 94–96. doi: 10.2340/00015555-1627 |
DOI: | https://doi.org/10.2340/00015555-1627 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | lymphoma |
Datum der Freischaltung: | 27.11.2015 |
Anmerkungen: | Der Zugang zum Volltext ist aus rechtlichen Gründen gesperrt. |
Lizenz (Deutsch): | Deutsches Urheberrecht |