Effects of estrogen receptor and Wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss
Please always quote using this URN: urn:nbn:de:bvb:20-opus-285487
- In the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact in a coordinated manner. Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate theIn the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact in a coordinated manner. Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate the underlying mechanisms as a basis for the development of new strategies in the treatment of osteoporosis. The present study aimed to investigate the effectiveness of the activation of the ligand-dependent ER and the Wnt/β-catenin signal transduction pathways on mechanically induced bone formation using ovariectomized mice as a model of postmenopausal bone loss. We demonstrated that both pathways interact in the regulation of bone mass adaption in response to mechanical loading and that the activation of Wnt/β-catenin signaling considerably increased mechanically induced bone formation, whereas the effects of estrogen treatment strictly depended on the estrogen status in the mice.…
Author: | Astrid Liedert, Claudia Nemitz, Melanie Haffner-Luntzer, Fabian Schick, Franz Jakob, Anita Ignatius |
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URN: | urn:nbn:de:bvb:20-opus-285487 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Lehrstuhl für Orthopädie |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2020 |
Volume: | 21 |
Issue: | 21 |
Article Number: | 8301 |
Source: | International Journal of Molecular Sciences (2020) 21:21, 8301. https://doi.org/10.3390/ijms21218301 |
DOI: | https://doi.org/10.3390/ijms21218301 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | ER signaling; Wnt/β-catenin signaling; bone remodeling; mechanotransduction; ovariectomy |
Release Date: | 2023/06/15 |
Date of first Publication: | 2020/11/05 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |