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Role of the pangolin in origin of SARS-CoV-2: an evolutionary perspective
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-285995
- After the recent emergence of SARS-CoV-2 infection, unanswered questions remain related to its evolutionary history, path of transmission or divergence and role of recombination. There is emerging evidence on amino acid substitutions occurring in key residues of the receptor-binding domain of the spike glycoprotein in coronavirus isolates from bat and pangolins. In this article, we summarize our current knowledge on the origin of SARS-CoV-2. We also analyze the host ACE2-interacting residues of the receptor-binding domain of spike glycoproteinAfter the recent emergence of SARS-CoV-2 infection, unanswered questions remain related to its evolutionary history, path of transmission or divergence and role of recombination. There is emerging evidence on amino acid substitutions occurring in key residues of the receptor-binding domain of the spike glycoprotein in coronavirus isolates from bat and pangolins. In this article, we summarize our current knowledge on the origin of SARS-CoV-2. We also analyze the host ACE2-interacting residues of the receptor-binding domain of spike glycoprotein in SARS-CoV-2 isolates from bats, and compare it to pangolin SARS-CoV-2 isolates collected from Guangdong province (GD Pangolin-CoV) and Guangxi autonomous regions (GX Pangolin-CoV) of South China. Based on our comparative analysis, we support the view that the Guangdong Pangolins are the intermediate hosts that adapted the SARS-CoV-2 and represented a significant evolutionary link in the path of transmission of SARS-CoV-2 virus. We also discuss the role of intermediate hosts in the origin of Omicron.…
Autor(en): | Shishir K. Gupta, Rashmi Minocha, Prithivi Jung Thapa, Mugdha Srivastava, Thomas Dandekar |
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URN: | urn:nbn:de:bvb:20-opus-285995 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften | |
Fakultät für Biologie / Center for Computational and Theoretical Biology | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 23 |
Heft / Ausgabe: | 16 |
Aufsatznummer: | 9115 |
Originalveröffentlichung / Quelle: | International Journal of Molecular Sciences (2022) 23:16, 9115. doi:10.3390/ijms23169115 |
DOI: | https://doi.org/10.3390/ijms23169115 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
Freie Schlagwort(e): | COVID-19; SARS-CoV-2; adaptation; comparative sequence analysis; evolution; intermediate host; mutation; origin; pangolin; recombination; transmission |
Datum der Freischaltung: | 20.04.2023 |
Datum der Erstveröffentlichung: | 14.08.2022 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |