Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Please always quote using this URN: urn:nbn:de:bvb:20-opus-223622
- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, itPsychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.…
Author: | Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos L. Santoro, Vanessa K. Ota, Cristiano Noto, Charles Curtis, Stephen J. Newhouse, Hamel Patel, Lynsey S. Hall, Paul F. O'Reilly, Sintia I. Belangero, Rodrigo A. Bressan, Gerome Breen |
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URN: | urn:nbn:de:bvb:20-opus-223622 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Language: | English |
Parent Title (English): | Communications Biology |
Year of Completion: | 2018 |
Volume: | 1 |
Article Number: | 163 |
Source: | Communications Biology (2018) 1:163. https://doi.org/10.1038/s42003-018-0155-y |
DOI: | https://doi.org/10.1038/s42003-018-0155-y |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | bipolar disorder; depression; genetic association study; genetic linkage study |
Release Date: | 2024/06/14 |
Creating Corporation: | Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium |
EU-Project number / Contract (GA) number: | 658195 |
OpenAIRE: | OpenAIRE |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |