Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo
Please always quote using this URN: urn:nbn:de:bvb:20-opus-239028
- Like human Th1 cells, mouse Th1 cells also secrete IFN‐γ upon stimulation with a superagonistic anti‐CD28 monoclonal antibody (CD28‐SA). Crosslinking of the CD28‐SA via FcR and CD40‐CD40L interactions greatly increased IFN‐γ release. Our data stress the utility of the mouse as a model organism for immune responses in humans.
Author: | Stephanie Haack, Sarah Baiker, Jan Schlegel, Markus Sauer, Tim Sparwasser, Daniela Langenhorst, Niklas Beyersdorf |
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URN: | urn:nbn:de:bvb:20-opus-239028 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften | |
Language: | English |
Parent Title (English): | European Journal of Immunology |
Year of Completion: | 2021 |
Volume: | 51 |
Issue: | 3 |
First Page: | 738 |
Last Page: | 741 |
Source: | European Journal of Immunology 2021, 51(3):738–741. DOI: 10.1002/eji.202048803 |
DOI: | https://doi.org/10.1002/eji.202048803 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | CD28; Superagonistic antibody; Th1 cells; cytokine release; interferon γ |
Release Date: | 2021/12/15 |
Licence (German): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |