Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid
Please always quote using this URN: urn:nbn:de:bvb:20-opus-67806
- Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
| Author: | Arne Homann, Riaz-ul Qamar, Sevnur Serim, Petra Dersch, Juergen Seibel |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-67806 |
| Document Type: | Journal article |
| Faculties: | Fakultät für Chemie und Pharmazie / Institut für Organische Chemie |
| Language: | English |
| Year of Completion: | 2010 |
| Source: | BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2010) 6, DOI: 10.3762/bjoc.6.24 |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| GND Keyword: | Organische Chemie |
| Tag: | bioorthogonal metabolic glycoengineering; click chemistry; sialic acid |
| Release Date: | 2012/07/04 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung |