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Probing the unknowns in cytokinin-mediated immune defense in Arabidopsis with systems biology approaches

Please always quote using this URN: urn:nbn:de:bvb:20-opus-120199
  • Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-proteinPlant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants.show moreshow less

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Metadaten
Author: Muhammad Naseem, Meik Kunz, Thomas Dandekar
URN:urn:nbn:de:bvb:20-opus-120199
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Bioinformatics and Biology Insights
ISSN:1177-9322
Year of Completion:2014
Volume:8
Pagenumber:35-44
Source:Bioinformatics and Biology Insights 2014:8 35–44 doi: 10.4137/BBI.S13462.
DOI:https://doi.org/10.4137/bbi.s13462
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24558299
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 572 Biochemie
Tag:cytokinin; gene expression; interaction networks; plant hormones; systems biology
Release Date:2016/02/11
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell