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Influence of Acute Complications on Outcome 3 Months after Ischemic Stroke
Please always quote using this URN: urn:nbn:de:bvb:20-opus-128362
- Background: Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke. Methods: Data were obtained from patients admitted to one of 13 stroke units of the Berlin Stroke Registry (BSR) who participated in a 3-months-follow up between June 2010 and September 2012. We examined the influence of the cumulative number of early in-hospital complications on mortality and poor outcome (death, disabilityBackground: Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke. Methods: Data were obtained from patients admitted to one of 13 stroke units of the Berlin Stroke Registry (BSR) who participated in a 3-months-follow up between June 2010 and September 2012. We examined the influence of the cumulative number of early in-hospital complications on mortality and poor outcome (death, disability or institutionalization) 3 months after stroke using multivariable logistic regression analyses and calculated attributable fractions to determine the impact of early complications on mortality and poor outcome. Results: A total of 2349 ischemic stroke patients alive at discharge from acute care were included in the analysis. Older age, stroke severity, pre-stroke dependency and early complications were independent predictors of mortality 3 months after stroke. Poor outcome was independently associated with older age, stroke severity, pre-stroke dependency, previous stroke and early complications. More than 60% of deaths and poor outcomes were attributed to age, pre-stroke dependency and stroke severity and in-hospital complications contributed to 12.3% of deaths and 9.1% of poor outcomes 3 months after stroke. Conclusion: The majority of deaths and poor outcomes after stroke were attributed to non-modifiable factors. However, early in-hospital complications significantly affect outcome in patients who survived the acute phase after stroke, underlining the need to improve prevention and treatment of complications in hospital.…
Author: | Maike Miriam Grube, Hans-Christian Koennecke, Georg Walter, Andreas Meisel, Jan Sobesky, Christian Hans Nolte, Ian Wellwood, Peter Ulrich Heuschmann |
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URN: | urn:nbn:de:bvb:20-opus-128362 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Klinische Epidemiologie und Biometrie |
Language: | English |
Parent Title (English): | PLOS ONE |
ISSN: | 1932-6203 |
Year of Completion: | 2013 |
Volume: | 8 |
Issue: | 9 |
Pagenumber: | e75719 |
Source: | PLoS ONE 8(9): e75719. doi:10.1371/journal.pone.0075719 |
DOI: | https://doi.org/10.1371/journal.pone.0075719 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Tag: | Barthel-Index; dependency; hospital medical complications; predictors; quality-of-care; rankin scale; reliability; risk-factors; term mortality; trial |
Release Date: | 2016/03/30 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |