A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites
Please always quote using this URN: urn:nbn:de:bvb:20-opus-250203
- Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable nicheSphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable niche for intracellular survival and proliferation. In contrast, some sphingolipid metabolites can also act as a first line defense against bacteria based on their antimicrobial activity. In this review, we will focus on the strategies employed by pathogenic Neisseria spp. to modulate the sphingolipid metabolism and hijack the sphingolipid balance in the host to promote cellular colonization, invasion and intracellular survival. Novel techniques and innovative approaches will be highlighted that allow imaging of sphingolipid derivatives in the host cell as well as in the pathogen.…
Author: | Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir |
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URN: | urn:nbn:de:bvb:20-opus-250203 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Hygiene und Mikrobiologie |
Language: | English |
Parent Title (English): | Cells |
ISSN: | 2073-4409 |
Year of Completion: | 2021 |
Volume: | 10 |
Issue: | 11 |
Article Number: | 3201 |
Source: | Cells 2021, 10(11), 3201; https://doi.org/10.3390/cells10113201 |
DOI: | https://doi.org/10.3390/cells10113201 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Neisseria gonorrhoeae; Neisseria meningitidis; host–pathogen interaction; sphingolipids |
Release Date: | 2022/02/01 |
Date of first Publication: | 2021/11/17 |
Open-Access-Publikationsfonds / Förderzeitraum 2021 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |