Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3
Please always quote using this URN: urn:nbn:de:bvb:20-opus-350099
- Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility ofSingle nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs.…
| Author: | Rhiannon V. McNeill, Franziska Radtke, Matthias Nieberler, Carolin Koreny, Andreas G. Chiocchetti, Sarah Kittel-Schneider |
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| URN: | urn:nbn:de:bvb:20-opus-350099 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
| Language: | English |
| Parent Title (English): | Stem Cell Research |
| Year of Completion: | 2023 |
| Volume: | 67 |
| Article Number: | 103016 |
| Source: | Stem Cell Research (2023) 67:103016. DOI: 10.1016/j.scr.2023.103016 |
| DOI: | https://doi.org/10.1016/j.scr.2023.103016 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | ADHD patients; gene ADGRL3; iPSCs; induced pluripotent stem cells; risk SNP rs1397547 |
| Release Date: | 2024/05/21 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |