Editorial: Cardiac Innervation Imaging as a Risk Stratification Tool for Potential Device Therapy Candidates
Please always quote using this URN: urn:nbn:de:bvb:20-opus-168465
- As a scintigraphic approach evaluating cardiac nerve integrity, \(^{123}\)I-metaiodobenzylguanidine (123I-mIBG) has been recently Food and Drug Administration approved. A great deal of progress has been made by the prospective ADMIRE-HF trial, which primarily demonstrated the association of denervated myocardium assessed by \(^{123}\)I-mIBG and cardiac events. However, apart from risk stratification, myocardial nerve function evaluated by molecular imaging should also be expanded to other clinical contexts, in particular to guide the referringAs a scintigraphic approach evaluating cardiac nerve integrity, \(^{123}\)I-metaiodobenzylguanidine (123I-mIBG) has been recently Food and Drug Administration approved. A great deal of progress has been made by the prospective ADMIRE-HF trial, which primarily demonstrated the association of denervated myocardium assessed by \(^{123}\)I-mIBG and cardiac events. However, apart from risk stratification, myocardial nerve function evaluated by molecular imaging should also be expanded to other clinical contexts, in particular to guide the referring cardiologist in selecting appropriate candidates for specific therapeutic interventions. In the present issue of the Journal of Nuclear Cardiology, the use of 123I-mIBG for identifying cardiomyopathy patients, which would most likely not benefit from ICD due low risk of arrhythmias, is described. If we aim to deliver on the promise of cardiac innervation imaging as a powerful tool for risk stratification in a manner similar to nuclear oncology, studies such as the one reviewed here may imply an important step to lay the proper groundwork for a more widespread adoption in clinical practice.…
Author: | Rudolf A. Werner |
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URN: | urn:nbn:de:bvb:20-opus-168465 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin |
Language: | English |
Parent Title (English): | Journal of Nuclear Cardiology |
ISSN: | 1071-3581 |
Year of Completion: | 2018 |
Source: | Journal of Nuclear Cardiology 2018 doi:10.1007/s12350-018-01475-0 |
URL: | https://rdcu.be/970i |
DOI: | https://doi.org/10.1007/s12350-018-01475-0 |
Sonstige beteiligte Institutionen: | Johns Hopkins Medicine |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | SPECT |
Tag: | 123I-mIBG; 123I-metaiodobenzylguanidine; ICD; SPECT; arrhythmia; cardiac innervation imaging; cardiac nerve; myocardial nerve |
Release Date: | 2018/10/29 |
Embargo Date: | 2019/10/24 |
EU-Project number / Contract (GA) number: | 701983 |
OpenAIRE: | OpenAIRE |
Note: | SharedIt-Link zur Publikation: https://rdcu.be/970i |
Note: | This is a post-peer-review, pre-copyedit version of an article published in Journal of Nuclear Cardiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-018-01475-0 |
Licence (German): | Deutsches Urheberrecht |