A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-250203
- Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable nicheSphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable niche for intracellular survival and proliferation. In contrast, some sphingolipid metabolites can also act as a first line defense against bacteria based on their antimicrobial activity. In this review, we will focus on the strategies employed by pathogenic Neisseria spp. to modulate the sphingolipid metabolism and hijack the sphingolipid balance in the host to promote cellular colonization, invasion and intracellular survival. Novel techniques and innovative approaches will be highlighted that allow imaging of sphingolipid derivatives in the host cell as well as in the pathogen.…
Autor(en): | Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir |
---|---|
URN: | urn:nbn:de:bvb:20-opus-250203 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Hygiene und Mikrobiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Cells |
ISSN: | 2073-4409 |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 10 |
Heft / Ausgabe: | 11 |
Aufsatznummer: | 3201 |
Originalveröffentlichung / Quelle: | Cells 2021, 10(11), 3201; https://doi.org/10.3390/cells10113201 |
DOI: | https://doi.org/10.3390/cells10113201 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Neisseria gonorrhoeae; Neisseria meningitidis; host–pathogen interaction; sphingolipids |
Datum der Freischaltung: | 01.02.2022 |
Datum der Erstveröffentlichung: | 17.11.2021 |
Open-Access-Publikationsfonds / Förderzeitraum 2021 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |