The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-137777
- The ubiquitin/proteasome system serves as a regulated protein degradation pathway in eukaryotes, and is involved in many cellular processes featuring high protein turnover rates, such as cell cycle control, stress response and signal transduction. In malaria parasites, protein quality control is potentially important because of the high replication rate and the rapid transformations of the parasite during life cycle progression. The proteasome is the core of the degradation pathway, and is a major proteolytic complex responsible for theThe ubiquitin/proteasome system serves as a regulated protein degradation pathway in eukaryotes, and is involved in many cellular processes featuring high protein turnover rates, such as cell cycle control, stress response and signal transduction. In malaria parasites, protein quality control is potentially important because of the high replication rate and the rapid transformations of the parasite during life cycle progression. The proteasome is the core of the degradation pathway, and is a major proteolytic complex responsible for the degradation and recycling of non-functional ubiquitinated proteins. Annotation of the genome for Plasmodium falciparum, the causative agent of malaria tropica, revealed proteins with similarity to human 26S proteasome subunits. In addition, a bacterial ClpQ/hslV threonine peptidase-like protein was identified. In recent years several independent studies indicated an essential function of the parasite proteasome for the liver, blood and transmission stages. In this review, we compile evidence for protein recycling in Plasmodium parasites and discuss the role of the 26S proteasome as a prospective multi-stage target for antimalarial drug discovery programs.…
Autor(en): | Animake Makoah Nigel, Hans-Dieter Arndt, Gabriele Pradel |
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URN: | urn:nbn:de:bvb:20-opus-137777 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | International Journal for Parasitology: Drugs and Drug Resistance |
Erscheinungsjahr: | 2012 |
Band / Jahrgang: | 2 |
Seitenangabe: | 1-10 |
Originalveröffentlichung / Quelle: | International Journal for Parasitology: Drugs and Drug Resistance 2 (2012) 1–10. DOI 10.1016/j.ijpddr.2011.12.001 |
DOI: | https://doi.org/10.1016/j.ijpddr.2011.12.001 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Freie Schlagwort(e): | inhibitor; plasmodium falciparum; proteasome; ubiquitin |
Datum der Freischaltung: | 26.08.2016 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2011 |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung |