Quantifying progression in primary progressive aphasia with structural neuroimaging
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-262605
- Introduction The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials.Introduction The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1‐year follow‐up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion PPA presents as a left‐dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant‐specific.…
Autor(en): | Jolina Lombardi, Benjamin Mayer, Elisa Semler, Sarah Anderl‐Straub, Ingo Uttner, Jan Kassubek, Janine Diehl‐Schmid, Adrian Danek, Johannes Levin, Klaus Fassbender, Klaus Fliessbach, Anja Schneider, Hans‐Jürgen Huppertz, Holger Jahn, Alexander Volk, Johannes Kornhuber, Bernhard Landwehrmeyer, Martin Lauer, Johannes Prudlo, Jens Wiltfang, Matthias L. Schroeter, Albert Ludolph, Markus Otto |
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URN: | urn:nbn:de:bvb:20-opus-262605 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Alzheimer's & Dementia |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 17 |
Heft / Ausgabe: | 10 |
Erste Seite: | 1595 |
Letzte Seite: | 1609 |
Originalveröffentlichung / Quelle: | Alzheimer's & Dementia 2021, 17(10):1595–1609. DOI: 10.1002/alz.12323 |
DOI: | https://doi.org/10.1002/alz.12323 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | atlas‐based volumetry; disease progression; frontotemporal dementia; longitudinal magnetic resonance imaging; primary progressive aphasia; sample size calculation |
Datum der Freischaltung: | 07.12.2022 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International |