Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems
Please always quote using this URN: urn:nbn:de:bvb:20-opus-61131
- The covalent binding of tritiated benzo(a)pyrene (BP) to DNA has been determined in rat liver in vivo, in rat liver perfused in situ, after incubation of BP with liver single cells, with liver homogenate, with liver microsomes and DNA, with fibroblasts from a rat granulorna pouch, and with · 2 cell lines. Li ver single cells were found to be a valuable compromise between the rnost sensitive system (microsomal incubation of BP with DNA) and the biologically most relevant system (in vivo ).
| Author: | W. Jaggi, Werner K. Lutz, C. Schlatter |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-61131 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
| Language: | English |
| Year of Completion: | 1979 |
| Source: | In: Experientia (1979) 35, 5, 631-2. |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| GND Keyword: | Toxikologie |
| Release Date: | 2012/01/27 |
| Licence (German): |  Deutsches Urheberrecht |