Intracellular staphylococcus aureus: Live-in and let die
Please always quote using this URN: urn:nbn:de:bvb:20-opus-123374
- Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells. The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cellStaphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells. The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cell death mechanisms such as apoptosis and pyronecrosis, and even can induce anti-apoptotic programs in phagocytes. The focus of this review is to present a guide to recent research outlining the variety of intracellular fates of S. aureus.…
Author: | Martin Fraunholz, Bhanu Sinha |
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URN: | urn:nbn:de:bvb:20-opus-123374 |
Document Type: | Journal article |
Faculties: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Language: | English |
Parent Title (English): | Frontiers in Cellular and Infection Microbiology |
Year of Completion: | 2012 |
Volume: | 2 |
Issue: | 43 |
Source: | Frontiers Cellular Infection Microbiology 2:43. doi:10.3389/fcimb.2012.00043 |
DOI: | https://doi.org/10.3389/fcimb.2012.00043 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 579 Mikroorganismen, Pilze, Algen |
Tag: | autophagy; bacterial persistence; host cell death; phagocytosis; phagosomalescape; staphylococcus aureus |
Release Date: | 2015/12/18 |
Licence (German): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |