Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men
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- Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany andMeningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany and included in the analysis. Genome sequencing revealed that the isolates from the outbreak among MSM and from urethritis cases belonged to a clade within clonal complex 11. Proteome analysis showed they expressed nitrite reductase, enabling anaerobic growth as previously described for gonococci. Invasive isolates from MSM, but not urethritis isolates, further expressed functional human factor H binding protein associated with enhanced survival in a newly developed transgenic mouse model expressing human factor H, a complement regulatory protein. In conclusion, our data suggest that urethritis and outbreak isolates followed a joint adaptation route including adaption to the urogenital tract.…
Autor(en): | Muhamed-Kheir Taha, Heike Claus, Martin Lappann, Frédéric J. Veyrier, Andreas Otto, Dörte Becher, Ala-Eddine Deghmane, Matthias Frosch, Wiebke Hellenbrand, Eva Hong, Isabelle Parent du Châtelet, Karola Prior, Dag Harmsen, Ulrich Vogel |
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URN: | urn:nbn:de:bvb:20-opus-179870 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Hygiene und Mikrobiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | PLoS ONE |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 11 |
Heft / Ausgabe: | 5 |
Aufsatznummer: | e0154047 |
Originalveröffentlichung / Quelle: | PLoS ONE 2016, 11(5):e0154047. DOI:10.1371/journal.pone.0154047 |
DOI: | https://doi.org/10.1371/journal.pone.0154047 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Neisseria gonorrhoeae; Neisseria meningitidis; genome sequencing; mammalian genomics; men who have sex with men; meningococcal disease; mouse models; nitrites |
Datum der Freischaltung: | 14.12.2020 |
EU-Projektnummer / Contract (GA) number: | 278864 |
OpenAIRE: | OpenAIRE |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |