Oral-health-related quality of life in patients with medication-related osteonecrosis of the jaw: a prospective clinical study
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-288141
- Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients’ OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of theMedication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients’ OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analog scales (VAS), and Satisfaction with Life Scale (SWLS) at baseline (T0), 10 days (T1), and 3 months after treatment (T2) in 36 patients. Data were analyzed using Kolmogorov–Smirnov test, two-way mixed ANOVAs, and follow-up Mann–Whitney U tests. The impact of treatment effects on the original seven OHIP domain structures and the recently introduced four-dimensional OHIP structure were evaluated using linear regression analysis. Thirty-six patients received surgical MRONJ treatment. Before treatment, patients’ perceived OHRQoL, oral discomfort, oral health, and satisfaction with life were negatively affected by MRONJ. Surgical treatment significantly improved OHRQoL and related parameters (all p ≤ 0.012). This improvement was greater in patients with higher impairment at T0. OHRQoL and oral restrictions were still impaired after treatment in patients who needed prosthetic treatment. The four-dimensional structure revealed valuable information beyond the standard seven OHIP domains. Increased awareness of MRONJ risks and an interdisciplinary treatment approach for MRONJ patients are needed.…
Autor(en): | Anna Winter, Stefan M. Schulz, Marc Schmitter, Roman C. Brands, Anton Straub, Alexander Kübler, Anna Borgmann, Stefan Hartmann |
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URN: | urn:nbn:de:bvb:20-opus-288141 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie |
Medizinische Fakultät / Poliklinik für Zahnärztliche Prothetik | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | International Journal of Environmental Research and Public Health |
ISSN: | 1660-4601 |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 19 |
Heft / Ausgabe: | 18 |
Aufsatznummer: | 11709 |
Originalveröffentlichung / Quelle: | International Journal of Environmental Research and Public Health (2022) 19:18, 11709. doi:10.3390/ijerph191811709 |
DOI: | https://doi.org/10.3390/ijerph191811709 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | OHIP-49; SWLS; medication-related osteonecrosis of the jaw; oral health; oral-health-related quality of life; satisfaction with life; treatment benefit |
Datum der Freischaltung: | 21.04.2023 |
Datum der Erstveröffentlichung: | 16.09.2022 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |