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Modulation of host signaling and cellular responses by Chlamydia
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-97225
- Modulation of host cell signaling and cellular functions is key to intracellular survival of pathogenic bacteria. Intracellular growth has several advantages e.g. escape from the humoral immune response and access to a stable nutrient rich environment. Growth in such a preferred niche comes at the price of an ongoing competition between the bacteria and the host as well as other microbes that compete for the very same host resources. This requires specialization and constant evolution of dedicated systems for adhesion, invasion andModulation of host cell signaling and cellular functions is key to intracellular survival of pathogenic bacteria. Intracellular growth has several advantages e.g. escape from the humoral immune response and access to a stable nutrient rich environment. Growth in such a preferred niche comes at the price of an ongoing competition between the bacteria and the host as well as other microbes that compete for the very same host resources. This requires specialization and constant evolution of dedicated systems for adhesion, invasion and accommodation. Interestingly, obligate intracellular bacteria of the order Chlamydiales have evolved an impressive degree of control over several important host cell functions. In this review we summarize how Chlamydia controls its host cell with a special focus on signal transduction and cellular modulation.…
Autor(en): | Thomas Rudel, Adrian Mehlitz |
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URN: | urn:nbn:de:bvb:20-opus-97225 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Cell Communication and Signaling |
Erscheinungsjahr: | 2013 |
Originalveröffentlichung / Quelle: | In: Cell Communication and Signaling (2013) 11: 90, doi:10.1186/1478-811X-11-90 |
URL der Erstveröffentlichung: | http://www.biosignaling.com/content/11/1/90 |
DOI: | https://doi.org/10.1186/1478-811X-11-90 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | Chlamydia; Inc; Inclusion; Invasion; Signaling; Tarp; Trafficking; Type III secretion |
Datum der Freischaltung: | 07.05.2014 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2013 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |