Neuroinflammation in Parkinson’s disease – putative pathomechanisms and targets for disease-modification
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-274665
- Parkinson’s disease (PD) is a progressive and debilitating chronic disease that affects more than six million people worldwide, with rising prevalence. The hallmarks of PD are motor deficits, the spreading of pathological α-synuclein clusters in the central nervous system, and neuroinflammatory processes. PD is treated symptomatically, as no causally-acting drug or procedure has been successfully established for clinical use. Various pathways contributing to dopaminergic neuron loss in PD have been investigated and described to interact withParkinson’s disease (PD) is a progressive and debilitating chronic disease that affects more than six million people worldwide, with rising prevalence. The hallmarks of PD are motor deficits, the spreading of pathological α-synuclein clusters in the central nervous system, and neuroinflammatory processes. PD is treated symptomatically, as no causally-acting drug or procedure has been successfully established for clinical use. Various pathways contributing to dopaminergic neuron loss in PD have been investigated and described to interact with the innate and adaptive immune system. We discuss the possible contribution of interconnected pathways related to the immune response, focusing on the pathophysiology and neurodegeneration of PD. In addition, we provide an overview of clinical trials targeting neuroinflammation in PD.…
Autor(en): | Alexander Grotemeyer, Rhonda Leah McFleder, Jingjing Wu, Jörg Wischhusen, Chi Wang Ip |
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URN: | urn:nbn:de:bvb:20-opus-274665 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Frauenklinik und Poliklinik |
Medizinische Fakultät / Neurologische Klinik und Poliklinik | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Immunology |
ISSN: | 1664-3224 |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 13 |
Aufsatznummer: | 878771 |
Originalveröffentlichung / Quelle: | Frontiers in Immunology (2022) 13:878771. DOI:10.3389/fimmu.2022.878771 |
DOI: | https://doi.org/10.3389/fimmu.2022.878771 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Parkinson’s disease; T cells; animal models; inflammatory cascades; microglia; neurodegeneration; neuroinflammation |
Datum der Freischaltung: | 13.04.2023 |
Datum der Erstveröffentlichung: | 18.05.2022 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |