Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice
Please always quote using this URN: urn:nbn:de:bvb:20-opus-141222
- Human gene association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety. In the present study genetically modified mice were utilised to examine the effects of changes in 5-HTT expression on anxiety. In addition, the influence of 5-HTT expression on two innate “species-typical” behaviours (burrowing and marble burying) and body weight was explored. Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout mice showedHuman gene association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety. In the present study genetically modified mice were utilised to examine the effects of changes in 5-HTT expression on anxiety. In addition, the influence of 5-HTT expression on two innate “species-typical” behaviours (burrowing and marble burying) and body weight was explored. Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout mice showed increased anxiety-like behaviour, compared to wildtype controls. In tests of species-typical behaviour 5-HTT overexpressing mice showed some facilitation whilst 5-HTT knockout mice were impaired. Reciprocal effects were also seen on body weight, as 5-HTT overexpressors were lighter and 5-HTT knockouts were heavier than wildtype controls. These findings show that variation in 5-HTT gene expression produces robust changes in anxiety and species-typical behaviour. Furthermore, the data add further support to findings that variation of 5-HTT expression in the human population is linked to changes in anxiety-related personality traits.…
Author: | Samantha J. Line, Christopher Barkus, Clare Coyle, Katie A. Jennings, Robert M. Deacon, Klaus P. Lesch, Trevor Sharp, David M. Bannerman |
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URN: | urn:nbn:de:bvb:20-opus-141222 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Language: | English |
Parent Title (English): | European Neuropsychopharmacology |
Year of Completion: | 2011 |
Volume: | 21 |
Issue: | 1 |
Pagenumber: | 108-116 |
Source: | European Neuropsychopharmacology (2011) 21, 108–116 |
DOI: | https://doi.org/10.1016/j.euroneuro.2010.08.005 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | 5-HT; 5-HT transporter; Anxiety; Body weight; Transgenic mice |
Release Date: | 2019/01/09 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |