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Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6
Please always quote using this URN: urn:nbn:de:bvb:20-opus-117254
- Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E.coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E.coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned betweenExtraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E.coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E.coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E.coli. STEC O2:H6 is, therefore, a 'heteropathogen,' and the first such hybrid virulent E.coli identified. The phylogeny of these E.coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E.coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed.…
Author: | Martina Bielaszewska, Roswitha Schiller, Lydia Lammers, Andreas Bauwens, Angelika Fruth, Barbara Middendorf, M. Alexander Schmidt, Phillip I. Tarr, Ulrich Dobrindt, Helge Karch, Alexander Mellmann |
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URN: | urn:nbn:de:bvb:20-opus-117254 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Language: | English |
Parent Title (English): | EMBO Molecular Medicine |
ISSN: | 1757-4684 |
Year of Completion: | 2014 |
Volume: | 6 |
Issue: | 3 |
Pagenumber: | 347-357 |
Source: | EMBO Molecular Medicine 2014 6(3):347-57. doi: 10.1002/emmm.201303133 |
DOI: | https://doi.org/10.1002/emmm.201303133 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24413188 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Crohns-disease; Shiga toxin-producing Escherichia coli; cytolethal distending toxin; genes; hemolytic-uremic syndrome; heteropathogenicity; island; outbreak; parallel evolution; phased metamorphosis; phylogeny; shiga toxin; strains; urinary-tract-infection; uropathogenic Escherichia coli |
Release Date: | 2015/08/17 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |