RNA structures and their role in selective genome packaging
Please always quote using this URN: urn:nbn:de:bvb:20-opus-246101
- To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examineTo generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.…
Author: | Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth |
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URN: | urn:nbn:de:bvb:20-opus-246101 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät |
Language: | English |
Parent Title (English): | Viruses |
ISSN: | 1999-4915 |
Year of Completion: | 2021 |
Volume: | 13 |
Issue: | 9 |
Article Number: | 1788 |
Source: | Viruses (2021) 13:9, 1788. https://doi.org/10.3390/v13091788 |
DOI: | https://doi.org/10.3390/v13091788 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | RNA; RNA structure; RNA virus; evolution; genome packaging; viral assembly |
Release Date: | 2022/11/23 |
Date of first Publication: | 2021/09/08 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |