NRF2‐dependent stress defense in tumor antioxidant control and immune evasion
Please always quote using this URN: urn:nbn:de:bvb:20-opus-224536
- The transcription factor NRF2 is known as the master regulator of the oxidative stress response. Tumor entities presenting oncogenic activation of NRF2, such as lung adenocarcinoma, are associated with drug resistance, and accumulating evidence demonstrates its involvement in immune evasion. In other cancer types, the KEAP1/NRF2 pathway is not commonly mutated, but NRF2 is activated by other means such as radiation, oncogenic activity, cytokines, or other pro‐oxidant triggers characteristic of the tumor niche. The obvious effect ofThe transcription factor NRF2 is known as the master regulator of the oxidative stress response. Tumor entities presenting oncogenic activation of NRF2, such as lung adenocarcinoma, are associated with drug resistance, and accumulating evidence demonstrates its involvement in immune evasion. In other cancer types, the KEAP1/NRF2 pathway is not commonly mutated, but NRF2 is activated by other means such as radiation, oncogenic activity, cytokines, or other pro‐oxidant triggers characteristic of the tumor niche. The obvious effect of stress‐activated NRF2 is the protection from oxidative or electrophilic damage and the adaptation of the tumor metabolism to changing conditions. However, data from melanoma also reveal a role of NRF2 in modulating differentiation and suppressing anti‐tumor immunity. This review summarizes the function of NRF2 in this tumor entity and discusses the implications for current tumor therapies.…
Author: | José Pedro Friedmann Angeli, Svenja Meierjohann |
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URN: | urn:nbn:de:bvb:20-opus-224536 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Pathologisches Institut |
Fakultät für Biologie / Rudolf-Virchow-Zentrum | |
Language: | English |
Parent Title (English): | Pigment Cell & Melanoma Research |
Year of Completion: | 2021 |
Volume: | 34 |
Issue: | 2 |
First Page: | 268 |
Last Page: | 279 |
Source: | Pigment Cell & Melanoma Research 2021, 34(2):268-279. DOI: 10.1111/pcmr.12946 |
DOI: | https://doi.org/10.1111/pcmr.12946 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | KEAP1; Nrf2; immune evasion; oxidative stress |
Release Date: | 2022/01/19 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |