Leaky gut as a potential culprit for the paradoxical dysglycemic response to gastric bypass-associated ileal microbiota
Please always quote using this URN: urn:nbn:de:bvb:20-opus-234085
- Altered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayersAltered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayers compromised barrier function and decreased expression of the barrier-stabilizing proteins claudin-4 and desmoglein-2. Our findings raise the possibility that RYGB-associated ileal microbiota produce and release soluble metabolites which locally increase intestinal permeability to promote systemic endotoxemia-induced insulin resistance, with potential implications for the treatment of RYGB patients who eventually relapse onto type 2 diabetes.…
Author: | Mohammed K. Hankir, Florian Seyfried, Isabel N. Schellinger, Nicolas Schlegel, Tulika Arora |
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URN: | urn:nbn:de:bvb:20-opus-234085 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Language: | English |
Parent Title (English): | Metabolites |
ISSN: | 2218-1989 |
Year of Completion: | 2021 |
Volume: | 11 |
Issue: | 3 |
Article Number: | 153 |
Source: | Metabolites (2021) 11:3, 153. https://doi.org/10.3390/metabo11030153 |
DOI: | https://doi.org/10.3390/metabo11030153 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Roux-en-Y gastric bypass surgery; intestinal epithelial barrier; intestinal microbiota; systemic endotoxemia; type 2 diabetes |
Release Date: | 2022/08/12 |
Date of first Publication: | 2021/03/08 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |