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Review of pharmacological therapies in fibromyalgia syndrome

Please always quote using this URN: urn:nbn:de:bvb:20-opus-121598
  • This review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial data, and observational studies. In the absence of a single gold-standard medication, patients are treated with a variety of drugs from different categories, often with limited evidence. Drug therapy is not mandatory for the management of FMS. Pregabalin, duloxetine, milnacipran, and amitriptyline are the current first-line prescribed agents but haveThis review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial data, and observational studies. In the absence of a single gold-standard medication, patients are treated with a variety of drugs from different categories, often with limited evidence. Drug therapy is not mandatory for the management of FMS. Pregabalin, duloxetine, milnacipran, and amitriptyline are the current first-line prescribed agents but have had a mostly modest effect. With only a minority of patients expected to experience substantial benefit, most will discontinue therapy because of either a lack of efficacy or tolerability problems. Many drug treatments have undergone limited study and have had negative results. It is unlikely that these failed pilot trials will undergo future study. However, medications, though imperfect, will continue to be a component of treatment strategy for these patients. Both the potential for medication therapy to relieve symptoms and the potential to cause harm should be carefully considered in their administration.show moreshow less

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Metadaten
Author: Winfried Häuser, Brian Walitt, Mary-Ann Fitzcharles, Claudia Sommer
URN:urn:nbn:de:bvb:20-opus-121598
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):Arthritis Research & Therapy
ISSN:1465-9913
Year of Completion:2014
Volume:16
Issue:201
Source:Arthritis Research & Therapy 2014, 16:201. doi:10.1186/ar4441
DOI:https://doi.org/10.1186/ar4441
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24433463
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Release Date:2016/02/19
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung