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Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity

Please always quote using this URN: urn:nbn:de:bvb:20-opus-127079
  • The harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous resistance against diverse pathogens. This study demonstrates that harmonine ((17R,9Z)-1,17-diaminooctadec-9-ene), which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens. Antibacterial activity is most pronounced againstThe harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous resistance against diverse pathogens. This study demonstrates that harmonine ((17R,9Z)-1,17-diaminooctadec-9-ene), which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens. Antibacterial activity is most pronounced against fast-growing mycobacteria and Mycobacterium tuberculosis, and the growth of both chloroquine-sensitive and -resistant Plasmodium falciparum strains is inhibited. Harmonine displays gametocytocidal activity, and inhibits the exflagellation of microgametocytes and zygote formation. In an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity.show moreshow less

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Metadaten
Author: Christian Rene Röhrich, Che Julius Ngwa, Jochen Wiesner, Henrike Schmidtberg, Thomas Degenkolb, Christian Kollewe, Rainer Fischer, Gabriele Pradel, Andreas Vilcinskas
URN:urn:nbn:de:bvb:20-opus-127079
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Molekulare Infektionsbiologie
Language:English
Parent Title (English):Biology Letters
Year of Completion:2012
Volume:8
Pagenumber:308-311
Source:Biology Letters (2012) 8, 308–311 doi:10.1098/rsbl.2011.0760
DOI:https://doi.org/10.1098/rsbl.2011.0760
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/21937493
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 579 Mikroorganismen, Pilze, Algen
Tag:antimicrobial activity; harmonia axyridis; harmonine; insect immunity
Release Date:2016/07/15
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung