Neural responses to a working memory task in acute depressed and remitted phases in bipolar patients
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-313509
- (1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute(1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associated brain activation during the acute phase of BD and to observe changes in the same patients during remission. (2) Frontal brain activation was recorded using functional near-infrared spectroscopy (fNIRS) during n-back task conditions (one-back, two-back and three-back) in BD patients in their acute depressive (n = 32) and remitted (n = 15) phases as well as in healthy controls (n = 30). (3) Comparison of BD patients during their acute phase with controls showed a trend (p = 0.08) towards lower dorsolateral prefrontal cortex (dlPFC) activation. In the remitted phase, BD patients showed lower dlPFC and ventrolateral prefrontal cortex (vlPFC) activation (p = 0.02) compared to controls. No difference in dlPFC and vlPFC activation between BD patients’ phases was found. (4) Our results showed decreased working memory performance in BD patients during the working memory task in the acute phase of disease. Working memory performance improved in the remitted phase of the disease but was still particularly attenuated for the more demanding conditions.…
Autor(en): | Juliane Kopf, Stefan Glöckner, Heike Althen, Thais Cevada, Martin Schecklmann, Thomas Dresler, Sarah Kittel-Schneider, Andreas Reif |
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URN: | urn:nbn:de:bvb:20-opus-313509 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Brain Sciences |
ISSN: | 2076-3425 |
Erscheinungsjahr: | 2023 |
Band / Jahrgang: | 13 |
Heft / Ausgabe: | 5 |
Aufsatznummer: | 744 |
Originalveröffentlichung / Quelle: | Brain Sciences (2023) 13:5, 744. https://doi.org/10.3390/brainsci13050744 |
DOI: | https://doi.org/10.3390/brainsci13050744 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | bipolar disorder; cognitive deficits; fNIRS; prefrontal cortex; remitted/acute phase; verbal n-back |
Datum der Freischaltung: | 18.01.2024 |
Datum der Erstveröffentlichung: | 29.04.2023 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |