Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-230079
- Objective To determine whether IgG subclasses of antiparanodal autoantibodies are related to disease course and treatment response in acute- to subacute-onset neuropathies, we retrospectively screened 161 baseline serum/CSF samples and 66 follow-up serum/CSF samples. Methods We used ELISA and immunofluorescence assays to detect antiparanodal IgG and their subclasses and titers in serum/CSF of patients with Guillain-Barre syndrome (GBS), recurrent GBS (R-GBS), Miller-Fisher syndrome, and acute- to subacute-onset chronic inflammatoryObjective To determine whether IgG subclasses of antiparanodal autoantibodies are related to disease course and treatment response in acute- to subacute-onset neuropathies, we retrospectively screened 161 baseline serum/CSF samples and 66 follow-up serum/CSF samples. Methods We used ELISA and immunofluorescence assays to detect antiparanodal IgG and their subclasses and titers in serum/CSF of patients with Guillain-Barre syndrome (GBS), recurrent GBS (R-GBS), Miller-Fisher syndrome, and acute- to subacute-onset chronic inflammatory demyelinating polyradiculoneuropathy (A-CIDP). We evaluated clinical data retrospectively. Results We detected antiparanodal autoantibodies with a prevalence of 4.3% (7/161), more often in A-CIDP (4/23, 17.4%) compared with GBS (3/114, 2.6%). Longitudinal subclass analysis in the patients with GBS revealed IgG2/3 autoantibodies against Caspr-1 and against anti-contactin-1/Caspr-1, which disappeared at remission. At disease onset, patients with A-CIDP had IgG2/3 anti-Caspr-1 and anti-contactin-1/Caspr-1 or IgG4 anti-contactin-1 antibodies, IgG3 being associated with good response to IV immunoglobulins (IVIg). In the chronic phase of disease, IgG subclass of one patient with A-CIDP switched from IgG3 to IgG4. Conclusion Our data (1) confirm and extend previous observations that antiparanodal IgG2/3 but not IgG4 antibodies can occur in acute-onset neuropathies manifesting as monophasic GBS, (2) suggest association of IgG3 to a favorable response to IVIg, and (3) lend support to the hypothesis that in some patients, an IgG subclass switch from IgG3 to IgG4 may be the correlate of a secondary progressive or relapsing course following a GBS-like onset.…
Autor(en): | Luise Appeltshauser, Anna-Michelle Brunder, Annika Heinius, Peter Körtvélyessy, Klaus-Peter Wandinger, Ralf Junker, Carmen Villmann, Claudia Sommer, Frank Leypoldt, Kathrin Doppler |
---|---|
URN: | urn:nbn:de:bvb:20-opus-230079 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Klinische Neurobiologie |
Medizinische Fakultät / Neurologische Klinik und Poliklinik | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Neurology: Neuroimmunology & Neuroinflammation |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 7 |
Heft / Ausgabe: | 5 |
Aufsatznummer: | e817 |
Originalveröffentlichung / Quelle: | Neurology: Neuroimmunology & Neuroinflammation (2020) 7(5):e817. DOI:10.1212/NXI.0000000000000817 |
DOI: | https://doi.org/10.1212/NXI.0000000000000817 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Guillain-Barre-Syndrome; autoantibodies; binding; biopsies; inflammatory demyelinating polyradiculoneuropathy; musk myasthenia gravis; neurofascin; ontactin 1; periperal nerve; switch |
Datum der Freischaltung: | 19.04.2021 |
OpenAIRE: | OpenAIRE |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2020 |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |