Long-term tumor control of spinal dissemination of cerebellar glioblastoma multiforme by combined adjuvant bevacizumab antibody therapy: a case report
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-110536
- Background Glioblastoma multiforme located in the posterior fossa is extremely rare with a frequency up to 3.4%. Compared with glioblastoma of the hemispheres the prognosis of infratentorial glioblastoma seems to be slightly better. Absence of brainstem invasion and low expression rates of epidermal growth factor receptor are described as factors for long-time survival due to the higher radiosensitivity of these tumors. Case presentation In this case study, we report a German female patient with an exophytic glioblastoma multiformeBackground Glioblastoma multiforme located in the posterior fossa is extremely rare with a frequency up to 3.4%. Compared with glioblastoma of the hemispheres the prognosis of infratentorial glioblastoma seems to be slightly better. Absence of brainstem invasion and low expression rates of epidermal growth factor receptor are described as factors for long-time survival due to the higher radiosensitivity of these tumors. Case presentation In this case study, we report a German female patient with an exophytic glioblastoma multiforme arising from the cerebellar tonsil and a secondary spinal manifestation. Furthermore, the tumor showed no O (6)-Methylguanine-DNA methyltransferase promotor-hypermethylation and no isocitrate dehydrogenase 1 mutations. All these signs are accompanied by significantly shorter median overall survival. A long-term tumor control of the spinal metastases was achieved by a combined temozolomide/bevacizumab and irradiation therapy, as part of a standard care administered by the treating physician team. Conclusion To our knowledge this is the first published case of a combined cerebellar exophytic glioblastoma with a subsequent solid spinal manifestation. Furthermore this case demonstrates a benefit undergoing this special adjuvant therapy regime in terms of overall survival. Due to the limited overall prognosis of the disease, spinal manifestations of glioma are rarely clinically relevant. The results of our instructive case, however, with a positive effect on both life quality and survival warrant treating future patients in the frame of a prospective clinical study.…
Autor(en): | Thomas Linsenmann, Camelia M. Monoranu, Giles H. Vince, Thomas Westermaier, Carsten Hagemann, Almuth F. Kessler, Ralf-Ingo Ernestus, Mario Löhr |
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URN: | urn:nbn:de:bvb:20-opus-110536 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Medizinische Fakultät / Pathologisches Institut | |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 2014 |
Originalveröffentlichung / Quelle: | BMC Research Notes 2014, 7:496. doi:10.1186/1756-0500-7-496 |
DOI: | https://doi.org/10.1186/1756-0500-7-496 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Bevacizumab; Glioblastoma; Irradiation; Spinal dissemination; Temozolomide |
Datum der Freischaltung: | 04.03.2015 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2014 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |