Transactivation of HIV by human spumaretrovirus
Please always quote using this URN: urn:nbn:de:bvb:20-opus-86436
- To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii)To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected.…
Author: | Axel Rethwilm, Gerald Baunach, Kazuyasu Mori, Volker ter Meulen |
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URN: | urn:nbn:de:bvb:20-opus-86436 |
Document Type: | Conference Proceeding |
Faculties: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Language: | English |
Year of Completion: | 1990 |
Source: | In: Progress in aids research in the Federal Republic of Germany / ed. Marianna Schauzu. - München: MMV, Medizin-Verl., 1990. - S. 31-33. - ISBN 3-8208-1140-0 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | HIV |
Release Date: | 2014/06/12 |
Licence (German): | Deutsches Urheberrecht |