Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy
Please always quote using this URN: urn:nbn:de:bvb:20-opus-220140
- The adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metabolic fitness needs to be optimal to reach the tumor and execute their cytolytic function in an environment often hostile. It is now well established that both tumor and T cell metabolisms play critical roles in controlling the immune response byThe adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metabolic fitness needs to be optimal to reach the tumor and execute their cytolytic function in an environment often hostile. It is now well established that both tumor and T cell metabolisms play critical roles in controlling the immune response by conditioning the tumor microenvironment and the fate and activity of the T cells. In this review, after a brief description of the tumoral and T cell metabolic reprogramming, we summarize the latest advances and new strategies that have been developed to improve the metabolic fitness and efficacy of CAR T-cell products.…
Author: | Marsha Pellegrino, Francesca Del Bufalo, Biagio De Angelis, Concetta Quintarelli, Ignazio Caruana, Emmanuel de Billy |
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URN: | urn:nbn:de:bvb:20-opus-220140 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Kinderklinik und Poliklinik |
Language: | English |
Parent Title (English): | Cells |
ISSN: | 2073-4409 |
Year of Completion: | 2020 |
Volume: | 10 |
Issue: | 1 |
Article Number: | 14 |
Source: | Cells (2021) 10:1, 14. https://doi.org/10.3390/cells10010014 |
DOI: | https://doi.org/10.3390/cells10010014 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Chimeric Antigen Receptor T cells; cancer; combined therapy; immunotherapy; metabolic reprogramming |
Release Date: | 2022/08/10 |
Date of first Publication: | 2020/12/24 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |