Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy
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- We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form theWe employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (≈10 ps) followed by decay (≈390 ps) to the corresponding ground state.…
Autor(en): | Pramod Kumar Verma, Andreas Steinbacher, Alexander Schmiedel, Patrick Nuernberger, Tobias Brixner |
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URN: | urn:nbn:de:bvb:20-opus-181301 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Chemie und Pharmazie / Institut für Physikalische und Theoretische Chemie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Structural Dynamics |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 3 |
Aufsatznummer: | 023606 |
Originalveröffentlichung / Quelle: | Structural Dynamics 2016, 3, 023606. DOI: 10.1063/1.4937363 |
DOI: | https://doi.org/10.1063/1.4937363 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 54 Chemie / 541 Physikalische Chemie |
Freie Schlagwort(e): | absorption spectra; excited states; fluorescence; fluorescence spectra; ground states; hydrogen bonding; reaction mechanisms; solvents; time resolved spectroscopy; ultraviolet light |
Datum der Freischaltung: | 15.03.2021 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |