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Alloreactivity of virus-specific T cells: possible implication of graft-versus-host disease and graft-versus-leukemia effects
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-129260
- Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, weImmune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells.…
Autor(en): | Shigeo Fuji, Markus Kapp, Hermann Einsele |
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URN: | urn:nbn:de:bvb:20-opus-129260 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Immunology |
Erscheinungsjahr: | 2013 |
Band / Jahrgang: | 4 |
Heft / Ausgabe: | 330 |
Originalveröffentlichung / Quelle: | Frontiers in Immunology 4:330. doi: 10.3389/fimmu.2013.00330 |
DOI: | https://doi.org/10.3389/fimmu.2013.00330 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | GVHD; GVL; HLA antigens; allogeneic stem cell transplantation; mismatch; virus-specific T-cell |
Datum der Freischaltung: | 22.06.2016 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |